Kakatiya Medical College we founded in 1959 by the Warangal Regional Medical Education society with the active support of the Chief Minister of Andhra Pradesh Neelam Sanjiva Reddy, the Director of Medical Services of A.P and the Warangal District Collector to provide medical education for register of the Telangana region of the state.

The College was inaugurated on 23 July 1959 by the Honourable Sri P. Karmarkar, Minister of Health, Government of India. It was originally located in a building donated by the Pingale family at Waddepally and it moved into the make-shift buildings constructed at the permanent site in November 1961.

152.17 acres (0.6158 km2) of land has acquired for the medical college in Warangal and the permanent building of the college was constructed at an estimated cost of about Rs. 47 lakhs. Mrs. Indira Gandhi, the then Prime Minister of India, inaugurated the permanent campus in 1966.

The temporary sheds which were constructed earlier at cost of Rs.10.70 Lakhs, in 1961 had been remodeled to the boy's hostel. The Permanent building for the girl's hostel was also constructed and Inaugurated by Sri J.Chokka Rao, Chairman A.P Regional Committee in 1970. A hostel for boys was inaugurated by Sri.H.C.Sarin I.C.S then advisor to Governor A.P on 20-06-1973.

An Impressive Auditorium with an open-air stage has constructed at cost of Rs. 4 Lakhs behind the College with Cinematographic equipment, accommodates 500 registers.

The A.P Housing board constructed staff quarters with a guest house in the college campus which fulfills the residential needs of staff. On either side of the college building, there are two buildings having a cloakroom, canteen, Andhra Bank, Post office & Engineering Depts.

In addition, R.M.E.S have constructed O.P. Block, T.B. Block, Lecture Hall, Clinical lab, and Mortuary in the premises of Mahatma Gandhi Memorial Hospital, Warangal.

The A.P Govt. took over the college from R.M.E.S. in Feb 1977. in the same year, The college affiliation was transferred to Kakatiya University from that of Osmania University. With effect from 1-03-87, the College has affiliated University of Health Sciences, now NTR University of Health Sciences, Vijayawada.

The P.G. Courses were started in 1972 and the college is conducting P.G courses in all the Depts. The present status college owes entirely to the great architect with the broad future vision of Late Prof. T.Lakshminarayana, the Dynamic Principal of the College (1960-1965).

All the P.G Courses are recognized by M.C.I, Medical Council of India.

In the year 2006-2007 Intermedics sports meet was conducted in our college with NTR U.H.S sponsoring for medical colleges& dental colleges in the state. The new N.M.H hostel was inaugurated by Hon'ble C.M, Dr.YS Rajasekhara Reddy.